Extracellular Milieu and Membrane Receptor Dual-Driven DNA Nanorobot for Accurate in Vivo Tumor Imaging

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

BACKGROUND There is growing awareness that tumour cells build up a "self-advantageous" microenvironment that reduces effectiveness of anti-tumour immune response. While many different immunosuppressive mechanisms are likely to come into play, recent evidence suggests that extracellular adenosine acting at A2A receptors may have a major role in down-modulating the immune response as cancerous ti...

Quantitative In Vivo Imaging of Breast Tumor Extracellular Matrix

A lyophilized peptide radiopharmaceutical kit to target neurotensin receptor for tumor imaging

Introduction: Neurotensin (NT) is a tridecapeptide that binds specifically to neurotensin receptors. Several forms of cancer, including small cell lung cancer, colon, pancreatic and prostate carcinomas especially exocrine pancreatic carcinomas express receptors for neurotensin peptide. Radiolabeled neurotensin derivatives with a high affinity for these receptors might be used for scintigraphy. ...

Design of Small Animal Computed Tomography Imaging for in vitro and in vivo Studies

Introduction: Mini Computed Tomography (mini-CT) was suggested in biomedical research to investigate tissues and small animals. We present designed and built a mini x-ray computed tomography (mini-CT) for small animals as well as industrial component imaging. Materials and Methods: The system used in this study includes a X-ray tube 20kV to 160kV and a flat pa...

Indocyanine Green Loaded Reduced Graphene Oxide for In Vivo Photoacoustic/Fluorescence Dual-Modality Tumor Imaging

Multimodality imaging based on multifunctional nanocomposites holds great promise to fundamentally augment the capability of biomedical imaging. Specifically, photoacoustic and fluorescence dual-modality imaging is gaining much interest because of their non-invasiveness and the complementary nature of the two modalities in terms of imaging resolution, depth, sensitivity, and speed. Herein, usin...